原创《地胆头化学成分其生理活性》：关于免费化学成分论文范文在这里免费下载与阅读,为您的化学成分相关论文写作提供资料。
摘 要 研究地胆头提取液中总多酚和类黄酮含量及其生理活性.测定了不同地胆头提取液的总多酚含量、类黄酮含量及其清除DPPH自由基的能力,并比较了不同料液比的地胆头提取液对血管紧张素转化酶（ACE）的抑制率.结果表明：不同提取剂提取的地胆头总多酚和类黄酮含量不同,其中,丙酮提取液中总多酚和类黄酮含量分别为12.27 mg/g、7.50 mg/g,均高于乙醇、甲醇、水提取液中的总多酚和类黄酮含量；地胆头丙酮、甲醇、乙醇提取液对DPPH 自由基的清除率分别为94.60%、93.41%、90.87%,均高于人工合成氧化剂BHT（89.15%）和地胆头水提取液（62.75%）；地胆头提取液对ACE的抑制效果随着料液比的增加而越明显,其中,1 ∶ 10的料液比下,乙醇地胆头提取液对ACE抑制率达到96.67%.通过本研究得出,在地胆头乙醇、甲醇、水、丙酮4种提取液中,丙酮提取液的总多酚和类黄酮含量最高,且其抗氧化性效果最佳,乙醇地胆头提取液的抗高血压能力最强.地胆头提取液具有明显的抗氧化性和抗高血压等生理活性,在功能食品及中草药领域里具有良好的开发应用前景.
关键词 地胆头；化学成分；生物活性；抗氧化性；抗高血压
中图分类号 S567.23 文献标识码 A
Abstract The polyphenol content, flavonoid content and DPPH scavenging activity of Elephantopus scaber（ES）extracts were detected, and the angiotensin converting enzyme（ACE）scavenging activity of ES extracts at different ratio solid-to-solvent were compared. The polyphenol and flavonoid content from ES with different extraction solvent were different, the polyphenol and flavonoid content of acetone extract was 12.27 mg/g and 7.50 mg/g, both higher than that of the methanol extract, ethanol extract, water extract. The DPPH scavenging activity of ES acetone extract, methanol extract and ethanol extract was 94.60%, 93.41%, 90.87%, respectively, which was higher than the DPPH scavenging activity of ES water extract and BHT； With the increasing of ratio solid-to-solvent, the ACE scavenging activity of ES extracts was better, the ACE scavenging activity of ES ethanol extract represented 96.67% at ratio solid-to-solvent of 1 ∶ 10. Among the four ES extracts, more polyphenol and flavonoid content were extracted by acetone than methanol, ethanol and water. And the antioxidant activity of ES acetone extract was the best. ES ethanol extract showed the best anti-hypertension. ES has great potential for the development of functional foods and herbs due to its excellent antioxidant activity and anti-hypertension activity.
Key words Elephantopus scaber； chemical constituents； bio-activity； antioxidant activity； anti-hypertension
doi 10.3969/j.issn.1000-2561.2017.06.025
地膽头（Elephantopus scaber）别名苦地胆、土公英等,属多年生草本,是中国长江以南常用的民间草药,并收录于《海南常见中草药名录》.地胆头有清热解毒、利尿消肿、治急性黄疸型肝炎和肝硬化腹水等功效[1].近代医学研究指出, 地胆头含有羽扇豆醇、豆甾醇和倍半萜类化合物——内酯、菊糖、果糖和氨基酸等化学成分, 其有效成分为倍半萜类化合物[2].地胆头全草对痢疾杆菌、金 葡萄球菌和大肠埃希氏菌有抑制作用.在国外,利用地胆头治疗糖尿病、肿瘤和肝炎等研究较广泛[3-6],在国内,对地胆头的研究大多是对其化学成分、微量元素、抗炎抗菌性和抗肿瘤等方面进行分析[7-10].在实际运用上,中国已有多个含地胆头的复方制剂应用于临床.此外,因为具有独特香味及药用功效,地胆头作为煲汤辅料被中国南方多省地使用[11].许多研究表明地胆头在保肝、抗糖尿病、抗高血压、抗肿瘤等生理活性上有巨大的潜在价值,但是目前对地胆头生理活性的整体性研究尚少见报道.
本研究定量测定了地胆头提取液中抗氧化成分总多酚和类黄酮的含量,并分别从DPPH清除率和ACE抑制率2方面对地胆头的生理活性进行评价,为地胆头资源的开发利用提供科研基础和理论依据.
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结论：地胆头化学成分其生理活性为适合不知如何写化学成分方面的相关专业大学硕士和本科毕业论文以及关于不含化学成分论文开题报告范文和相关职称论文写作参考文献资料下载。
