分类筛选
分类筛选:

关于白细胞计数论文范文资料 与单纯人免疫缺陷病毒感染者脑脊液白细胞计数水平和分析有关论文参考文献

版权:原创标记原创 主题:白细胞计数范文 科目:毕业论文 2024-02-27

《单纯人免疫缺陷病毒感染者脑脊液白细胞计数水平和分析》:关于免费白细胞计数论文范文在这里免费下载与阅读,为您的白细胞计数相关论文写作提供资料。

摘 要 目的:研究单纯人免疫缺陷病毒(human immunodeficiency virus, HIV)感染者脑脊液白细胞计数水平及其影响因素.方法:收集2009年8月—2015年6月间在我院治疗且无中枢神经系统感染及颅内占位病变的HIV感染者的人口学和临床资料.结果:共有86例患者进入本研究,他们的脑脊液白细胞计数中位数为2/μl,其中66例的脑脊液白细胞计数水平<5/μl.与脑脊液白细胞计数水平处于正常范围者相比,脑脊液白细胞计数水平偏高者的平均年龄及CD4细胞计数水平均显著更大和更高.CD4细胞计数水平≥300/μl者出现脑脊液白细胞计数水平偏高的可能性是CD4细胞计数水平<300/μl者的4.53倍.结论:单纯HIV感染者外周血CD4细胞计数水平与脑脊液白细胞计数水平间存在相关性.

关键词 人免疫缺陷病毒感染 脑脊液 白细胞计数 中枢神经系统感染

中图分类号:R512.91 文献标识码:B 文章编号:1006-1533(2017)11-0007-04

Analysis of white blood cell count in cerebrospinal fluid of patients with simple human immunodeficiency virus infection

SUN Jianjun1*, WANG Jiangrong1, LU Hongzhou1,2**(1. Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China;

2. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China)

ABSTRACT Objective: To analyze the distribution of white blood cell (WBC) count in cerebrospinal fluid (C*) of patients with simple human immunodeficiency virus (HIV) infection and its risk factors. Methods: Demographic and clinical data from HIV-infected patients without central nervous system infection and occupying lesions who were treated in our hospital from August, 2009 to June, 2015 were collected and respectively analyzed. Results: Total 86 HIV-infected patients were involved in this study and the medium of their WBC count in C* was 2/μl, in which there were 66 cases with WBC count in C* less than 5/μl. The mean age and CD4 cell count of patients with higher WBC count in C* were significantly elder and higher than those of patients with WBC count in normal range. The risk for occurring higher WBC count in C* in patients with CD4 cell count over 300/μl was 4.53 folds in patients with CD4 cell count down 300/μl. Conclusion: There is a correlation between CD4 cell count in peripheral blood and WBC count in C*.

KEY WORDS human immunodeficiency virus infection; cerebrospinal fluid; white blood cell counts; central nervous system infection

自人免疫缺陷病毒(human immunodeficiency virus, HIV)被發现并被证实为艾滋病病原体以来,快速蔓延的艾滋病疫情已成为全球公共卫生领域的沉重负担[1-3].由于HIV主要感染以CD4+ T淋巴细胞为主的免疫细胞,所以随着HIV感染时间的延长,大多数患者的免疫系统功能将逐渐衰竭,最终出现严重的机会性感染及肿瘤[4-6].对HIV感染的临床观察及基础研究发现,HIV感染可导致中枢神经系统病变[7],出现HIV相关脑病并使脑脊液所含细胞数发生相应改变[8-9],如白细胞计数水平较非HIV感染者高等[10].因此,有关HIV感染合并梅毒的临床诊疗指南[11-12]指出,对血清梅毒螺旋体颗粒凝集(Treponema pallidum particle agglutination, TPPA)试验和甲苯胺红不加热血清试验(toluidine red unheated serum test, TRUST)结果呈阳性者,若腰椎穿刺检查发现其脑脊液白细胞计数水平>20/μl,则排除其他可能引起脑脊液白细胞计数水平升高的原因后亦可诊断为神经梅毒.和此同时,也有研究提示,单纯HIV感染对脑脊液白细胞计数水平的影响较小[13].但关于单纯HIV感染者的脑脊液白细胞计数水平究竟如何,至今还无明确结论.为此,本研究选取已排除了常见中枢神经系统感染及颅内占位病变的HIV感染者,对他们的脑脊液白细胞计数水平进行分析.

白细胞计数论文参考资料:

结论:单纯人免疫缺陷病毒感染者脑脊液白细胞计数水平和分析为关于本文可作为白细胞计数方面的大学硕士与本科毕业论文血常规白细胞计数偏高论文开题报告范文和职称论文论文写作参考文献下载。

和你相关的