原创《西格列汀联合门冬地特胰岛素对2型糖尿病患者血糖波动影响》：这篇西格论文范文为免费优秀学术论文范文,可用于相关写作参考。
[摘 要] 目的 探讨西格列2型糖尿病患者血糖波动的影响. 方法 将2016年11月—2017年5月该院收治的40例血糖控制不佳的2型糖尿病患者汀为研究对象,随机分成对照组、实验组各20例.在相同生活方式干预下,对照组给予门冬及地特胰岛素,实验组在对照组基础上加用西格列汀（100 mg/d）,1周后通过监测7次指尖血糖,比较患者治疗前后血糖改善状况及两组间血糖波动状况、低血糖发生频率. 结果 治疗前比较两组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白（HbA1c）、体重指数（BMI）、胆固醇（TC）、甘油三酯（TG）、收缩压、舒张压、病程等,均差异无统计学意义（P>0.05）.治疗后两组血糖较治疗前均有明显改善（P<0.05）,且实验组血糖波动指标：血糖水平标准差（SDBG）、变异系数（CV）、餐后血糖波动幅度（PPGE）较对照组低（P<0.05）.两组患者均未出现明显低血糖等不良事件. 结论 西格列汀联合门冬及地特胰岛素可在有效降低血糖的基础上减少血糖波动.
[关键词] 西格列汀；门冬胰岛素；地特胰岛素；血糖波动
[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2017）10（a）-0025-04
Research on Effect of Sitagliptin Combined with Aspart and Insulin Detemir on the Fluctuation of Blood Glucose of Patients with Type 2 Diabetes
CHEN Jun1, QI Hao2
1.Shanxi Medical University, Taiyuan, Shanxi Province, 030001 China；2.Department of Endocrinology,First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, 030001 China
[Abstract] Objective To study the effect of sitagliptin combined with aspart and insulin detemir on the fluctuation of blood glucose of patients with type 2 diabetes. Methods 40 cases of type 2 diabetes with bad blood glucose control from November 2016 to May 2017 were divided into two groups with 20 cases in each, under the precondition of the same lifestyle, the control group were treated with aspart and insulin detemir, while the experimental group were treated with sitagliptin （100 mg/d） on the basis of the control group, and the 7 fingertip blood glucose was monitored after 1 week, and the improvement of blood glucose, blood glucose fluctuation and incidence rate of hypoglycemia were compared before and after treatment. Results Before treatment, the differences in the fasting blood glucose, postprandial 2 h blood glucose, HbA1c, BMI, TC, TG, systolic pressure, dilation pressure, and disease course between the two groups were not statistically significant（P>0.05）, after treatment, the blood glucose of the two groups was obviously improved compared with that before treatment（P<0.05）, and the SDBG, CV and PPGE were lower than those in the control group（P<0.05）, both groups had no adverse events such as obvious hypoglycemia. Conclusion Sitagliptin combined with aspart and insulin detemir can effectively reduce the fluctuation of blood glucose on the basis of decreasing the blood glucose.
[Key words] Sitagliptin； Insulin aspart； Insulin detemir； Fluctuation of blood glucose
我國糖尿病患病率呈快速增长趋势,且控制形势不容乐观,近10年来糖尿病患者的血糖控制虽有所改善,但仍不能满足对于并发症控制的要求[1].2型糖尿病（T2DM）并发症的发生和发展和血糖的波动性密切相关, 血糖波动性越高, 慢性并发症的危险性越大.
西格论文参考资料：
结论：西格列汀联合门冬地特胰岛素对2型糖尿病患者血糖波动影响为关于西格方面的论文题目、论文提纲、上海西格女装专柜论文开题报告、文献综述、参考文献的相关大学硕士和本科毕业论文。
