原创《还原型谷胱甘肽联合前列地尔治疗慢性肾功能不全疗效》：本文关于还原型谷胱甘肽论文范文,可以做为相关论文参考文献,与写作提纲思路参考。
[摘 要] 目的 研究还原型谷胱甘肽联合前列地尔治疗慢性肾功能不全的临床疗效.方法 研究对象方便选取2016年4月—2017年7月期间该院收治的80例慢性肾功能不全患者,采用随机抽取法将其分为对照组和观察组,每组40例.对照组患者予以注射稀释后的还原型谷胱甘肽进行治疗,观察组患者在此基础上注射稀释的前列地尔进行治疗,比较两组患者肾功能的治疗疗效.结果 观察组患者的治疗总有效率（80.0%）显著高于对照组的（57.5%）（χ2等于4.71,P等于0.02）；治疗后,观察组患者的Scr（247.62±20.03）μmol/L、BUN（15.64±6.12）mmol/L、CD4+-Treg（27.68±11.67）%、CD4+CD25+CD127-Treg（15.17±6.44）%水平明显低于对照组（307.72±36.27）μmol/L、（20.59±7.21）mmol/L、（35.22±11.24）%、（19.51±8.96）%,Ccr（32.51±17.54）mL/min、Hb（90.78±18.36）g/L、Alb（39.06±14.19）g/L水平明显高于对照组（25.13±5.63）mL/min、（83.14±12.77）g/L、（32.52±8.48）g/L（P<0.05）.结论 使用还原型谷胱甘肽联合前列地尔治疗慢性肾功能不全患者的疗效显著,值得临床推广.
[关键词] 谷胱甘肽；前列地尔；慢性肾功能；临床疗效
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2018）01（b）-0105-03
[Abstract] Objective To research the clinical effect of reduced glutathione hormone combined with alprostadil in treatment of chronic renal insufficiency. Methods 80 cases of patients with chronic renal insufficiency admitted and treated in our hospital from April 2016 to July 2017 were commodiously selected and randomly divided into two groups with 40 cases in each, the control group were treated with reduced glutathione hormone after the dilution, while the observation group were injected with alprostadil on the basis of the control group, and the treatment curative effect was compared between the two groups. Results The total treatment effective rate in the observation group was obviously higher than that in the control group, （80.0% vs 57.5%）, （χ2等于4.71,P等于0.02）, after treatment, the Scr, BUN, CD4+-Treg, CD4+CD25+CD127-Treg levels in the observation group were obviously lower than those in the control group[（247.62±20.03）μmol/L, （15.64±6.12）mmol/L, （27.68±11.67）%, （15.17±6.44）% vs （307.72±36.27）μmol/L,（20.59±7.21）mmol/L,（35.22±11.24）%,（19.51±8.96）%], and the Ccr, Hb and Alb in the observation group were obviously higher than those in the control group[（32.51±17.54mL/min）, （90.78±18.36）g/L, （39.06±14.19）g/L vs （25.13±5.63）mL/min,（83.14±12.77）g/L,（32.52±8.48）g/L]（P<0.05）. Conclusion The curative effect of reduced glutathione hormone combined with alprostadil in treatment of chronic renal insufficiency is obvious, which is worth clinical promotion.
[Key words] Glutathione hormone； Alprostadil； Chronic renal function； Clinical curative effect
慢性腎功能不全是指患者因各种因素导致明显的肾萎缩,进一步引起代谢产物病理性储存、堆积,并伴有电解质失衡等微样变化,患者免疫力不断下降,各种代谢功能均受到不良影响[1].慢性肾功能不全在现代较为普遍,目前尚未能够彻底治愈,故现代医学最主要的研究方向是干扰和阻断其发展成尿毒症[2].还原性谷胱甘肽和前列地尔在临床上皆可用于治疗慢性肾功能不全,缓解患者病情[3]但单独使用的效果不够显著.还原性谷胱甘肽是一种天然多肽,由谷氨酸、半胱氨酸和甘氨酸组成的,前列地尔是一种调节免疫系统的药物,其可用于阻碍免疫细胞发挥识别抗原作用[4].有研究表明[5],还原型谷胱甘肽联合前列地尔在理论上可以协调治疗慢性肾功能不全,提高治疗效率.目前国内关于两种药物联合使用的报道较少,故笔者采用还原型谷胱甘肽联合前列地尔治疗2016年4月—2017年7月期间该院收治的80例慢性肾功能不全患者,观察其治疗疗效,旨在为临床用药提供指导,现报道如下.
还原型谷胱甘肽论文参考资料：
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